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sql server, microsoft sql server, can you use sql server, sql server 2008

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do you have to use mysql with this, or can you connect it to a microsoft sql server?

HESK requires MySQL, it does not support MS SQL.

Not sure if PHP itself supports connecting to Microsoft SQL Server.
MySQL, Sqlite and Postgres yes.

Sure it does, just needs to be enabled
http://php.net/manual/en/book.mssql.php